Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Potassium (elemental) (from 619 mg Potassium Gluconate)
99 mg
2%
Top Medical Research Studies
9
We examined whether activating M-type potassium channels in the left stellate ganglion could help manage heart issues during acute myocardial ischemia (AMI). In our study involving beagles, some received an M-channel activator called retigabine before inducing AMI.
The results were promising—we noticed that retigabine reduced excessive sympathetic activity, leading to fewer arrhythmias. Moreover, it allowed for better heart rhythm stability and increased resistance to ventricular fibrillation compared to those who did not receive treatment. These insights suggest that targeting M-channels could be a valuable approach in reducing heart rhythm disturbances during ischemic events.
The results were promising—we noticed that retigabine reduced excessive sympathetic activity, leading to fewer arrhythmias. Moreover, it allowed for better heart rhythm stability and increased resistance to ventricular fibrillation compared to those who did not receive treatment. These insights suggest that targeting M-channels could be a valuable approach in reducing heart rhythm disturbances during ischemic events.
9
We investigated how ICA-105574, an HERG channel activator, might alleviate severe long QT syndrome type 2 (LQT2) caused by critical genetic mutations. Our study included in vivo experiments with animal models and in vitro tests that showcased ICA-105574's ability to shorten cardiac repolarization intervals.
We found it effectively restored ion currents impacted by harmful mutations. Our findings indicate that ICA-105574 has potential as a therapeutic option and highlight the usefulness of molecular dynamics simulations in drug design for managing HERG-related conditions.
We found it effectively restored ion currents impacted by harmful mutations. Our findings indicate that ICA-105574 has potential as a therapeutic option and highlight the usefulness of molecular dynamics simulations in drug design for managing HERG-related conditions.
9
We explored how AMPK, when activated, enhances potassium channels known as K2.3 in endothelial cells, which could improve vascular health. Through various laboratory techniques, we found that AMPK activation increased the phosphorylation of K2.3, leading to better blood flow in mouse models of hypertension. This process seems to reduce early hypertension caused by angiotensin II. Our findings suggest that AMPK could be a valuable target for therapies aimed at treating endothelial dysfunction and hypertension.
Most Useful Reviews
9
Essential for health
Potassium is vital for the normal functioning of the cardiovascular and nervous systems, as well as for restoring physical strength and endurance.
9
Vital nutrient
Potassium is essential for the proper functioning of the cardiovascular and nervous systems, along with the restoration of physical strength and endurance.
7.5
Improved well-being
Potassium gluconate has become an excellent supplement for maintaining potassium levels in the body. This mineral is crucial for the proper functioning of the heart, nervous system, and muscles. Since I began taking it, I have noticed a significant improvement in my overall well-being, particularly in alleviating muscle spasms and fatigue. The product aids in maintaining water and electrolyte balance, which is essential during physical activity. The capsules are easy to digest and do not cause any discomfort. This is an excellent choice for those seeking to support the cardiovascular system and enhance muscle function, especially if there is a deficiency of potassium in the diet.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
- All Researches
9
We investigated how ICA-105574, an HERG channel activator, might alleviate severe long QT syndrome type 2 (LQT2) caused by critical genetic mutations. Our study included in vivo experiments with animal models and in vitro tests that showcased ICA-105574's ability to shorten cardiac repolarization intervals.
We found it effectively restored ion currents impacted by harmful mutations. Our findings indicate that ICA-105574 has potential as a therapeutic option and highlight the usefulness of molecular dynamics simulations in drug design for managing HERG-related conditions.
We found it effectively restored ion currents impacted by harmful mutations. Our findings indicate that ICA-105574 has potential as a therapeutic option and highlight the usefulness of molecular dynamics simulations in drug design for managing HERG-related conditions.
9
We explored how AMPK, when activated, enhances potassium channels known as K2.3 in endothelial cells, which could improve vascular health. Through various laboratory techniques, we found that AMPK activation increased the phosphorylation of K2.3, leading to better blood flow in mouse models of hypertension. This process seems to reduce early hypertension caused by angiotensin II. Our findings suggest that AMPK could be a valuable target for therapies aimed at treating endothelial dysfunction and hypertension.
9
We examined whether activating M-type potassium channels in the left stellate ganglion could help manage heart issues during acute myocardial ischemia (AMI). In our study involving beagles, some received an M-channel activator called retigabine before inducing AMI.
The results were promising—we noticed that retigabine reduced excessive sympathetic activity, leading to fewer arrhythmias. Moreover, it allowed for better heart rhythm stability and increased resistance to ventricular fibrillation compared to those who did not receive treatment. These insights suggest that targeting M-channels could be a valuable approach in reducing heart rhythm disturbances during ischemic events.
The results were promising—we noticed that retigabine reduced excessive sympathetic activity, leading to fewer arrhythmias. Moreover, it allowed for better heart rhythm stability and increased resistance to ventricular fibrillation compared to those who did not receive treatment. These insights suggest that targeting M-channels could be a valuable approach in reducing heart rhythm disturbances during ischemic events.
8
We examined the link between potassium levels and the effectiveness of a fixed-dose combination (FDC) of telmisartan and amlodipine in treating hypertension. Our study took place in Dhaka, where we screened individuals for potassium imbalances before and after treatment.
Despite concerns about dyskalemia, we found low rates of both high and low potassium levels among patients. Additionally, the treatment effectively lowered blood pressure, making it a suitable option in settings where lab access is limited.
Overall, this suggests that we can confidently proceed with this treatment regimen.
Despite concerns about dyskalemia, we found low rates of both high and low potassium levels among patients. Additionally, the treatment effectively lowered blood pressure, making it a suitable option in settings where lab access is limited.
Overall, this suggests that we can confidently proceed with this treatment regimen.
8
We assessed the effectiveness of a salt reduction project in Zhejiang Province, China, focusing on blood pressure and potassium levels. Through thorough surveys and a randomized group approach, we found significant changes post-intervention.
Participants in the intervention areas showed an impressive increase in urinary potassium excretion and a notable decrease in both sodium intake and blood pressure levels. This suggests that a comprehensive, community-focused strategy can effectively tackle high-salt diets and improve cardiovascular health.
Participants in the intervention areas showed an impressive increase in urinary potassium excretion and a notable decrease in both sodium intake and blood pressure levels. This suggests that a comprehensive, community-focused strategy can effectively tackle high-salt diets and improve cardiovascular health.
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential for health
Potassium is vital for the normal functioning of the cardiovascular and nervous systems, as well as for restoring physical strength and endurance.
9
Vital nutrient
Potassium is essential for the proper functioning of the cardiovascular and nervous systems, along with the restoration of physical strength and endurance.
7.5
Improved well-being
Potassium gluconate has become an excellent supplement for maintaining potassium levels in the body. This mineral is crucial for the proper functioning of the heart, nervous system, and muscles. Since I began taking it, I have noticed a significant improvement in my overall well-being, particularly in alleviating muscle spasms and fatigue. The product aids in maintaining water and electrolyte balance, which is essential during physical activity. The capsules are easy to digest and do not cause any discomfort. This is an excellent choice for those seeking to support the cardiovascular system and enhance muscle function, especially if there is a deficiency of potassium in the diet.
Frequently Asked Questions
7.5
Improved well-being
Potassium gluconate has become an excellent supplement for maintaining potassium levels in the body. This mineral is crucial for the proper functioning of the heart, nervous system, and muscles. Since I began taking it, I have noticed a significant improvement in my overall well-being, particularly in alleviating muscle spasms and fatigue. The product aids in maintaining water and electrolyte balance, which is essential during physical activity. The capsules are easy to digest and do not cause any discomfort. This is an excellent choice for those seeking to support the cardiovascular system and enhance muscle function, especially if there is a deficiency of potassium in the diet.
9
Essential for health
Potassium is vital for the normal functioning of the cardiovascular and nervous systems, as well as for restoring physical strength and endurance.
References
- Kumawat A, Tavazzani E, Lentini G, Trancuccio A, Kukavica D, et al. Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations. J Biomed Sci. 2025;32:40. doi:10.1186/s12929-025-01134-w
- Ishigami J, Hasan MM, Sarker A, Nahar S, Shuvo SS, et al. Dyskalemia Prior to and After Initiation of a Fixed Dose Combination of Telmisartan and Amlodipine in Adults with Hypertension in Bangladesh. Glob Heart. 2025;20:30. doi:10.5334/gh.1415
- Pang ZD, Wang Y, Han MZ, She G, Sun X, et al. AMPK phosphorylation of K2.3 alleviates angiotensin II-induced endothelial dysfunction. Biochem Pharmacol. 2025;236:116880. doi:10.1016/j.bcp.2025.116880
- Peng JQ, Zhou MM, Xu L, Wang X, Tang YH, et al. Targeted M-Channel Activation in the Left Stellate Ganglion Protects Against Ischemia-Induced Ventricular Arrhythmias in Canines. J Am Heart Assoc. 2025;14:e039059. doi:10.1161/JAHA.124.039059
- Du X, Zhu Y, Guo J, Chen X, Zhang J, et al. Effect of Salt Reduction Interventions in Lowering Blood Pressure and Salt Intake in Zhejiang Province, China, 2017-2021: A Randomized Controlled Trial. Nutrients. 2025;17. doi:10.3390/nu17050893
- Liebman SE, Baran A, Barnett TD, Campbell TM, Chen L, et al. The Effects of a Whole-Food Plant-Based Nutrition Education Program on Blood Pressure and Potassium in Chronic Kidney Disease: A Proof-of-Concept Study. Nutrients. 2025;17. doi:10.3390/nu17050779
- Zhang X, Yao S, Wang Y, Chu C, Du M, et al. Associations of microRNA Gene Polymorphisms With Salt Sensitivity, Longitudinal Blood Pressure Changes, and Hypertension Incidence in the Chinese Population. J Clin Hypertens (Greenwich). 2025;27:e70019. doi:10.1111/jch.70019
